Genetic testing in consecutive cases of acute and clinically suspected myocarditis with noise in the family

Abstract Background Myocarditis is increasingly associated with dilated cardiomyopathy (DCM) and arrhythmogenic (ACM). Purpose The aim of our study was to define if a genetic predisposition exists in cases myocarditis suspicious findings inherited cardiovascular disease (noise) the family. Methods Consecutive patients referred unit from 2010 2021, presentation acute or clinically suspected myocarditis, as defined by current criteria, went through family screening first second-degree relatives. Patients fulfilling typical criteria for definite ARVC upon were excluded. familial (familial noise) including a. history sudden cardiac death, b. c. suggestive relatives (ECG abnormalities, complex frequent ventricular arrhythmias, conduction disease, troponemia, structural abnormalities cardiomyopathy) analysis 90 genes cardiomyopathy. Results Fifty-five noise included (Table 1). In 49 (89%) ≥2 diagnostic fulfilled. 50% patients, revealed there no relevant history. Myocardial inflammation confirmed 16 (29%) histological on endomyocardial biopsy Lake Louise Criteria magnetic resonance. Pathogenic likely pathogenic variants identified 78% (figure Desmoplakin (24%) followed lamin A/C (13%) titin (9%) most common identified. myocardial yield increased 87%. Conclusions A significant proportion “familial noise” carry variant related gene. These potentially affect clinical management need myocarditis. Funding Acknowledgement Type funding sources: Public grant(s) – National budget only. Main source(s): Greek Network Precision Medicine Cardiology Prevention Sudden Cardiac Death Young, icardiacnet